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Article

A Data-Driven Approach to Predicting 5-Aminolevulinic Acid-Induced Fluorescence and World Health Organization Grade in Newly Diagnosed Diffuse Gliomas.

Neurosurgery - 1 Jun 2022

Müther Michael, Jaber Mohammed, Johnson Timothy D, Orringer Daniel A, Stummer Walter

Abstract excerpt

BACKGROUND: A growing body of evidence has revealed the potential utility of 5-aminolevulinic acid (5-ALA) as a surgical adjunct in selected lower-grade gliomas. However, a reliable means of identifying which lower-grade gliomas will fluoresce has not been established. OBJECTIVE: To identify clinical and radiological factors predictive of intraoperative fluorescence in intermediate-grade gliomas. In addition,...

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PMID: 35285461
DOI: 10.1227/neu.0000000000001914
PMCID: PMC9067086

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