Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos

Abstract excerpt

<h4>ABSTRACT</h4> The oviduct is the site of fertilization and preimplantation embryo development in mammals. Evidence suggests that gametes alter oviductal gene expression. To delineate the adaptive interactions between the oviduct and gamete/embryo, we performed a multi-omics characterization of oviductal tissues utilizing bulk RNA-sequencing (RNA-seq), single-cell RNA-sequencing (scRNA-seq), and proteomics col...

Topics

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• Chemokines, CXC
• Embryo Implantation
• Endometriosis Research and Treatment
• Endometrium
• Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Reproductive Biology and Fertility
• Reproductive System and Pregnancy
• Sperm and Testicular Function

Identifiers and source

Literature Corpus work

4a478cc0-45d6-5d27-aacd-e14c0cfeec85

DOI

10.1101/2024.06.13.598905