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An m6A methyltransferase confers host resistance by degrading viral proteins through ubiquitination

24 May 2025

Abstract excerpt

Posttranscriptional and posttranslational modifications play crucial roles in plant immunity. However, how plants fine-tune such modifications to activate antiviral immunity remains unknown. Here, we report that the m6A methyltransferase TaHAKAI is utilized by wheat yellow mosaic virus (WYMV) to increase viral genomic m6A modification and promote viral replication. However, TaHAKAI also functions as an E3 ligase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40410199
DOI: 10.1038/s41467-025-60199-1

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