Article
Disrupted development of sensory systems and the cerebellum in a zebrafish ebf3a mutant.
G3 (Bethesda, Md.) - 9 Jul 2025
Dang Nghi D P, Barcus Alexia K, Conklin Claire L, Truong Thinh Q, Vivian Michael D, Wang Jun, Thomas Holly R, Parant John M, Yeo Nan Cher, Thyme Summer B
Abstract excerpt
Mutations in the transcription factor early B cell factor 3 result in a neurodevelopmental disorder, and studies in animal models indicate that it has a critical role in neuronal differentiation. The molecular pathways and neuron types disrupted by its loss, however, have not been thoroughly investigated. Nor have the outcomes of these changes on behavior and brain activity. Here, we generated and characterized a...
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