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Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells

21 May 2025

Abstract excerpt

Gonadotrophs are the essential pituitary endocrine cells for reproduction. They produce both luteinizing (LH) and follicle-stimulating (FSH) hormones that act on the gonads to promote germ cell maturation and steroidogenesis. Their secretion is controlled by the hypothalamic gonadotrophin-releasing hormone (GnRH), and gonadal steroid feedback. Gonadotrophs first appear in the embryonic pituitary, along with other...

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PMID: 40399281
DOI: 10.1038/s41467-025-59495-7

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