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SARS-CoV-2 variants and bebtelovimab: immune escape mechanisms revealed by computational studies.

Physical chemistry chemical physics : PCCP - 11 Dec 2024

Roy Rakesh Kumar, Sharma Madhur, Patra Niladri

Abstract excerpt

The receptor binding domain (RBD) of SARS-CoV-2 (coronavirus) targets and facilitates the binding with the human ACE2 receptor and is also a target for most monoclonal antibodies for the inhibition process. The emerging mutations in the RBD of SARS-CoV-2 are problematic, as their local and non-local effects can disrupt the binding mechanism of the antibody with the coronavirus's viral protein, thus compromising...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39618233
DOI: 10.1039/d4cp03031a

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