Article
The Relation of Multiple Sclerosis to Family History, Lifestyle, and Health Factors in Childhood and Adolescence: Findings of a Case-Control Study Nested Within the German National Cohort (NAKO) Study.
Deutsches Arzteblatt international - 27 Jun 2025
Holz Anja, Obi Nadia, Pischon Tobias, Schulze Matthias B, Ahrens Wolfgang, Berger Klaus, Bohn Barbara, Brenner Hermann, Emmel Carina, Fischer Beate, Greiser Karin Halina, Harth Volker, Holleczek Bernd, Kaaks Rudolf, Karch André, Katzke Verena, Keil Thomas, Krist Lilian, Leitzmann Michael, Meinke-Franze Claudia, Michels Karin B, Nimptsch Katharina, Peters Annette, Riedel Oliver, Schikowski Tamara, Schipf Sabine, Schmidt Börge, Thierry Sigrid, Hellwig Kerstin, Riemann-Lorenz Karin, Heesen Christoph, Becher Heiko
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is a neuroinflammatory disease of presumed autoimmune origin. A combination of genetic susceptibility and exposure to certain environmental and lifestyle factors might trigger the onset of MS. The currently known risk factors include a genetic predisposition, infection with the Epstein-Barr virus (EBV), smoking, and an increased body mass index. METHODS: In 2021-22, we carried...
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