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Article

Silencing ZIC5 suppresses glycolysis and promotes disulfidptosis in lung adenocarcinoma cells

14 May 2025

Abstract excerpt

Objective This study aims to explore the effects of silencing Zic family member 5 (ZIC5) on glucose metabolism and disulfidptosis in lung adenocarcinoma (LUAD) cells.Methods Data from The Cancer Genome Atlas (TCGA) was used to analyze ZIC5 expression in LUAD and its association with patient outcomes. ZIC5 was silenced in A549 and H1299 cells using siRNA. The expression of ZIC5 mRNA and protein was assessed by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40366858
DOI: 10.1080/15384047.2025.2501780

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