Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program.

doi:10.1093/hmg/ddaf075

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Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program.

Human molecular genetics - 11 May 2026

Pathak Gita A, Koller Dora, Cabrera-Mendoza Brenda, Nono Djotsa Alice B S, Wendt Frank R, De Lillo Antonella, Friligkou Eleni, He Jun, Kouakou Manuela R, Duong Linh M, Vahey Jacqueline, Steele Lea, Quaden Rachel, Harrington Kelly M, Ahmed Sarah T, Gaziano J Michael, Concato John, Zhao Hongyu, Radhakrishnan Krishnan, Gelernter Joel, Gifford Elizabeth, Aslan Mihaela, Helmer Drew A, Hauser Elizabeth R, Polimanti Renato

Abstract excerpt

Gulf War Illness (GWI) is a multi-symptom chronic condition that affects Veterans who served in the 1990-1991 Gulf War (GW). To generate novel information about GWI pathogenesis, we used genome-wide data available from 33 523 Veterans of diverse ancestral backgrounds who served during the 1990-1991 Gulf War era (34% deployed). Polygenic score (PGS) analysis showed GWI pleiotropy for several traits with the...

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PMID: 40366759
DOI: 10.1093/hmg/ddaf075

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AGXT
MAB21L4

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