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Article

Multitrait GWAS of non-suicidal self-injury and the polygenetic effects on child psychopathology and brain structures

1 May 2025

Abstract excerpt

Non-suicidal self-injury (NSSI) is highly prevalent in recent years, but the genetic architecture remains unknown. We perform a multitrait analysis of genome-wide association study on NSSI, incorporating self-harm and suicide attempt. Common genetic variants account for 6.03% of NSSI variance. Three risk loci are associated with NSSI at 7q31.2 (rs62474683), DCC (rs4372758), and LCA5L/GET1/GET1-SH3BGR (rs2837022)....

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PMID: 40347941
DOI: 10.1016/j.xcrm.2025.102119

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