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From discovery to potential application: engineering a novel M23 peptidase to combat Listeria monocytogenes

5 May 2025

Abstract excerpt

Peptidoglycan hydrolases are promising alternatives for combating pathogens due to their specificity and potent bacteriolytic activity. In this study, a novel M23 peptidase from Streptococcus thermophilus NCTC10353, designated StM23, was discovered and characterized. It exhibited antibacterial activity against Listeria monocytogenes and other Gram-positive bacteria with meso-DAP-type peptidoglycan, including...

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PMID: 40325189
DOI: 10.1038/s41598-025-99141-2

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