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Two cinnamic acid derivatives as inhibitors of Pseudomonas aeruginosa las and pqs quorum-sensing systems: Impact on biofilm formation and virulence factors

1 May 2025

Abstract excerpt

INTRODUCTION: Quorum sensing (QS) is a bacterial communication mechanism that regulates gene expression, playing a crucial role in various physiological processes. Interfering with this signalling pathway is a promising strategy to control bacterial pathogenicity and virulence. OBJECTIVES: This study evaluated the potential of two cinnamic acid derivatives, ferulic and sinapic acids, to inhibit the las and pqs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40318447
DOI: 10.1016/j.biopha.2025.118090

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