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Article

TP53 and CDKN2A alterations define a poor prognostic subgroup in patients with nodal T follicular helper cell lymphoma.

Leukemia - 1 Jul 2025

Ito Yuta, Shimono Joji, Kawamoto Keisuke, Hatanaka Kanako C, Kogure Yasunori, Tabata Mariko, Saito Yuki, Mizuno Kota, Horie Sara, Mizukami Yosuke, Koya Junji, Murakami Koichi, Teshima Takanori, Hatanaka Yutaka, Chiba Kenichi, Okada Ai, Shiraishi Yuichi, Miyoshi Hiroaki, Matsuno Yoshihiro, Ohshima Koichi, Kataoka Keisuke, Nakagawa Masao

Abstract excerpt

Nodal T follicular helper cell lymphoma (nTFHL) exhibits unique immunophenotypes and somatic alterations, while the prognostic value of these alterations remains unclear. By analyzing 173 nTFHL cases, we identified 36 driver genes, including 4 novel ones (TET3, HLA-C, NRAS, and KLF2). Then, we classified nTFHL cases into four molecular subgroups by major driver alterations. TR-I (+) and TR-I (-) were...

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Identifiers

PMID: 40316697
DOI: 10.1038/s41375-025-02631-5

Genes

CDKN2A
TP53
IDH2
KLF2
NRAS
RHOA
TET2
TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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