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Article

Deep phenotypic analysis of psychiatric features in genetically defined cohorts: application to XYY syndrome.

Journal of neurodevelopmental disorders - 20 Feb 2023

Raznahan Armin, Rau Srishti, Schaffer Luke, Liu Siyuan, Fish Ari M, Mankiw Catherine, Xenophontos Anastasia, Clasen Liv S, Joseph Lisa, Thurm Audrey, Blumenthal Jonathan D, Bassett Dani S, Torres Erin N

Abstract excerpt

BACKGROUND: Recurrent gene dosage disorders impart substantial risk for psychopathology. Yet, understanding that risk is hampered by complex presentations that challenge classical diagnostic systems. Here, we present a suite of generalizable analytic approaches for parsing this clinical complexity, which we illustrate through application to XYY syndrome. METHOD: We gathered high-dimensional measures of...

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Identifiers

PMID: 36803654
DOI: 10.1186/s11689-023-09476-y
PMCID: PMC9940341

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