Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice.

doi:10.1093/oxfordjournals.jhered.a110101

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Article

Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice.

The Journal of heredity - 1 Jan 2000

Ahmed F, Shire J G

Abstract excerpt

Beige, bg, and reduced pigmentation, rp, are recessive mutations affecting lysosomal function. Homozygosity for beige prevented lipofuscinosis of the spleen in C57BL mice and its incidence was greatly reduced by homozygosity for rp. Dilute (d) homozygotes, with normal lysosomes, were susceptible to lipofuscinosis even though their melanosomes were more severely affected than those of beige mice.

Topics

Animals
Crosses, Genetic
Genotype
Heterozygote
Homozygote
Lipofuscin
Lysosomes
Mice
Mice, Inbred C57BL
Mutation
Pigments, Biological
Spleen
Splenic Diseases

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