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Article

Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility.

Biomolecules - 9 Apr 2025

Tudor Lucija, Podobnik Josip, Nedic Erjavec Gordana, Nikolac Perkovic Matea, Harro Jaanus, Kanarik Margus, Marcinko Darko, Svob Strac Dubravka, Cusek Melita, Kovac Vlatka, Pivac Nela

Abstract excerpt

Aggression constitutes a significant behavioral issue associated with delinquent behavior, commonly observed in youth diagnosed with conduct disorder (CD) and living in correctional facilities. Catechol-o-methyl-transferase (COMT) gene variants modify the environmental sensitivity associated with the risk of aggression. This study evaluated the association of COMT rs4680 and rs4818 polymorphisms with aggressive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40305338
DOI: 10.3390/biom15040554
PMCID: PMC12024663

Genes

COMT
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility.PMID 40305338Read ↗

Study of the catechol-o-methyltransferase (COMT) gene with high aggression in children.Semantic proximity Read ↗

Association between S-COMT activity and impulsive and premeditated aggression in a population of violent offenders: preliminary results of a cross sectional studySemantic proximity Read ↗

Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment.Semantic proximity Read ↗

Catecholamines and aggression: the role of COMT and MAO polymorphisms.Semantic proximity Read ↗

COMT Val158Met genotype as a risk factor for problem behaviors in youth.Semantic proximity Read ↗

Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents.Semantic proximity Read ↗

[Association between aggressive behaviors and COMT Val158Met and 5-HTTLPR polymorphisms in children].Semantic proximity Read ↗

Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients.Semantic proximity Read ↗

Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms.Semantic proximity Read ↗

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic StudiesSemantic proximity Read ↗

Associations between the COMT rs4680 Gene Polymorphism and Personality Dimensions and Anxiety in Patients with a Diagnosis of Other Stimulants DependenceSemantic proximity Read ↗

Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study.Semantic proximity Read ↗

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