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Article

Study of the catechol-o-methyltransferase (COMT) gene with high aggression in children.

Aggressive behavior - 1 Jan 2013

Hirata Yuko, Zai Clement C, Nowrouzi Behdin, Beitchman Joseph H, Kennedy James L

Abstract excerpt

The etiology of childhood-onset aggression (COA) is poorly understood, but early COA can be considered as a strong risk factor for adult delinquency and criminal behavior. Callous-unemotional (CU) traits have been proposed as a developmental model of antisocial behavior. Catechol O-methyltransferase (COMT) has been associated with aggression, attention deficit/hyperactivity disorder (ADHD), and other psychiatric...

Topics

Adolescent
Aggression
Antisocial Personality Disorder
Catechol O-Methyltransferase
Child
Child Behavior
Conduct Disorder
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Male

Polymorphism, Single Nucleotide

Sex Factors

Source

Identifiers

PMID: 22972758
DOI: 10.1002/ab.21448

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Study of the catechol-o-methyltransferase (COMT) gene with high aggression in children.PMID 22972758Read ↗

Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility.Semantic proximity Read ↗

COMT Val158Met genotype as a risk factor for problem behaviors in youth.Semantic proximity Read ↗

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic StudiesSemantic proximity Read ↗

Effects of NR3C1 and COMT Genes on Attention-Deficit/Hyperactivity Disorder and Accompanying Aggressiveness: A Cross-Sectional Study in a Clinical Sample.Semantic proximity Read ↗

Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism.Semantic proximity Read ↗

Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.Semantic proximity Read ↗

Catecholamines and aggression: the role of COMT and MAO polymorphisms.Semantic proximity Read ↗

Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment.Semantic proximity Read ↗

Association between S-COMT activity and impulsive and premeditated aggression in a population of violent offenders: preliminary results of a cross sectional studySemantic proximity Read ↗

[Association between aggressive behaviors and COMT Val158Met and 5-HTTLPR polymorphisms in children].Semantic proximity Read ↗

The association between the catechol-O-methyltransferase Val108/158Met polymorphism and hyperactive-impulsive and inattentive symptoms in youth.Semantic proximity Read ↗

A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).Semantic proximity Read ↗

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