Article
Association of gene variant type and location with breast cancer risk in the general population.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Aug 2025
Akamandisa M P, Boddicker N J, Yadav S, Hu C, Hart S N, Ambrosone C B, Anton-Culver H, Auer P L, Bodelon C, Burnside E S, Chen F, Eliassen A H, Goldgar D E, Haiman C, Hodge J M, Huang H, John E M, Karam R, Lacey J V, Lindstroem S, Martinez M E, Na J, Neuhausen S L, O'Brien K M, Olson J E, Pal T, Palmer J R, Patel A V, Pesaran T, Polley E C, Richardson M E, Ruddy K J, Sandler D P, Teras L R, Trentham-Dietz A, Vachon C M, Weinberg C, Winham S J, Yao S, Zirpoli G, Kraft P, Weitzel J N, Domchek S M, Couch F J, Nathanson K L
Abstract excerpt
BACKGROUND: Pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 are associated with increased breast cancer risk. It is unknown, however, whether this risk differs by PV type or location in carriers ascertained from the general population. PATIENTS AND METHODS: To evaluate breast cancer risks associated with PV type and location in ATM, BRCA1, BRCA2, CHEK2, and PALB2, we carried out age-adjusted...
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