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Application of single-cell RNA sequencing analysis of novel breast cancer phenotypes based on the activation of ferroptosis-related genes.

Functional & integrative genomics - 22 May 2023

Liu Shuochuan, Zhao Yajie, Zhang Jiao, Liu Zhenzhen

Abstract excerpt

Ferroptosis is distinct from classic apoptotic cell death characterized by the accumulation of reactive oxygen species (ROS) and lipid peroxides on the cell membrane. Increasing findings have demonstrated that ferroptosis plays an important role in cancer development, but the exploration of ferroptosis in breast cancer is limited. In our study, we aimed to establish a ferroptosis activation-related model based on...

Topics

Humans
Ferroptosis
Apoptosis
Carcinoma
Phenotype
Sequence Analysis, RNA
Tumor Microenvironment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37212877
DOI: 10.1007/s10142-023-01086-0
PMCID: PMC10203036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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