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Article

Impact of Gene-Smoking Interaction on Risk of Atherosclerosis: Molecular Study of Prothrombin (F2) Gene rs1799963 G/A Polymorphism in Atherosclerotic Patients.

Cardiovascular toxicology - 1 Jun 2025

Abbas Farrakh Ali, Batool Shazia, Hina Moazma, Khalid Tayyba, Aman Amna, Awan Fazli Rabbi, Hussain Misbah

Abstract excerpt

Atherosclerosis is a multifactorial disease influenced by genetic and lifestyle factors (e.g., smoking). The rs1799963 G/A polymorphism in the prothrombin (F2) gene is associated with thrombosis and cardiovascular diseases. However, the interaction between this genetic variant and smoking on the risk of atherosclerosis has not been thoroughly investigated. This study aims to explore the impact of rs1799963...

Read the complete abstract on PubMed

Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Female

Middle Aged

Prothrombin

Genetic Predisposition to Disease

Smoking

Polymorphism, Single Nucleotide

Atherosclerosis

Risk Assessment

Case-Control Studies

Phenotype

Pakistan

Genetic Association Studies

Adult

Risk Factors

Aged

Gene Frequency

Source

Identifiers

PMID: 40261540
DOI: 10.1007/s12012-025-09997-z

Genes

F2

Provenance

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