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Article

Post-traumatic stress disorder and systemic lupus erythematosus: insights from a systematic review.

Rheumatology (Oxford, England) - 1 Sept 2025

Parperis Konstantinos, Papachristodoulou Maria, Derk Chris, Psarelis Savvas, Voskarides Konstantinos, Chatzittofis Andreas

Abstract excerpt

OBJECTIVES: Emerging evidence suggests that post-traumatic stress disorder (PTSD) may increase susceptibility to autoimmune diseases, including SLE. PTSD-related immune dysregulation is hypothesized to heighten vulnerability to autoimmunity. This systematic review sought to evaluate the relationship between PTSD and the risk of developing SLE, as well as explore potential shared genetic predispositions. METHODS:...

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PMID: 40257431
DOI: 10.1093/rheumatology/keaf220

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