Article
A genetic variant associated with aquaporin 3 expression is correlated to in-hospital death in COVID-19 patients with extracellular hyperosmolality.
Physiological genomics - 1 Jun 2025
Marks-Hultström Michael, Marks Amanda M, Butler-Laporte Guillaume, Yoshiji Satoshi, Lu Tianyuan, Morrison Dave R, Nakanishi Tomoko, Chen Yiheng, Forgetta Vincenzo, Farjoun Yossi, Frithiof Robert, Lipcsey Miklos, Zeberg Hugo, Richards J Brent
Abstract excerpt
Hyperosmolality is increasingly recognized as a factor contributing to severe COVID-19. Recently, a genetic variant near the aquaporin 3 (AQP3) water channel was associated with severe COVID-19 [rs60840586:G; odds ratio (OR): 1.07, P = 2.5 × 10-9]. The variant is known to increase gene expression of AQP3 in several organs, including the lung [normalized expression scores (NES) = 0.33, P = 4.1 × 10-20] in GTEx. In...
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