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Autoimmunity in inflammatory bowel disease: a holobiont perspective

18 Apr 2025

Abstract excerpt

Adaptive immunity towards self-antigens (autoimmunity) and intestinal commensal microbiota is a key feature of inflammatory bowel disease (IBD). Considering mucosal adaptive immunity from a holobiont perspective, where the host and its microbiome form a single physiological unit, emphasises the challenge of avoiding damaging responses to self-antigen and symbiotic microbial communities in the gut while protecting...

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PMID: 40252635
DOI: 10.1016/j.coi.2025.102557

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