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Article

Causal relationship between graves' disease and mental disorders: A bidirectional Mendelian randomization study.

Journal of psychosomatic research - 1 May 2025

Deng Yuanyuan, Hao Zejin, Chen Wen, Zhang Junping, Zou Yun, Zhang Jie, Xi Yanhua, Xu Jixiong

Abstract excerpt

OBJECTIVE: Many patients with Graves' disease (GD) also suffer from mental disorders in clinical practice, but their causal relationship remains unclear. This study aims to investigate the causal relationship between GD and common mental disorders using a bidirectional Mendelian randomization (MR)approach. METHODS: We derived genome-wide association study (GWAS) data for common mental disorders, including major...

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Anxiety Disorders
Attention Deficit Disorder with Hyperactivity
Bipolar Disorder
Genome-Wide Association Study
Graves Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Major Depressive Disorder

Mendelian Randomization Analysis

Mental Disorders

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PMID: 40209607
DOI: 10.1016/j.jpsychores.2025.112124

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