Article
Intertwined and unequal causality of type 1 diabetes and autoimmune thyroid disease: Insights from Mendelian randomization.
Medicine - 21 Nov 2025
Wu Jingyi, Yu Yunfeng, Shangguan Xueli, Yang Xinyu, Yu Rong, Zhou Chuanlong
Abstract excerpt
The relationship between type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) remains controversial. This study aims to analyze the potential causal relationship between T1D and AITD using bidirectional Mendelian randomization (MR). Single nucleotide polymorphisms associated with T1D, autoimmune thyroiditis (AIT), and Graves' disease (GD) were sourced from FinnGen. Inverse variance weighted, MR-Egger, and...
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