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A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer

11 Jun 2012

Abstract excerpt

Infection by carcinogenic human papillomaviruses (HPV) results in precancers [cervical intraepithelial neoplasia (CIN)] and cancers near the ectoendocervical squamocolumnar (SC) junction of the cervix. However, the specific cells targeted by HPV have not been identified and the cellular origin of cervical cancer remains elusive. In this study, we uncovered a discrete population of SC junctional cells with unique...

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PMID: 22689991
DOI: 10.1073/pnas.1202684109

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