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Article

Partial redundancy buffers deleterious effects of mutating DNA methyltransferase 1-1 (MET1-1) in polyploid wheat.

Journal of experimental botany - 17 Jun 2025

Burrows Samuel, Dorussen Delfi, Crudgington Joseph, Di Santolo Giorgia, Simmonds James, Catoni Marco, Borrill Philippa

Abstract excerpt

DNA methylation plays important roles in gene expression, transposable element silencing, and genome stability. Altering DNA methylation could generate additional phenotypic variation for crop breeding, however the lethality of epigenetic mutants in crop species has hindered its investigation. Here, we exploit partial redundancy between homoeologues in polyploid wheat to generate viable mutants in the DNA...

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Identifiers

PMID: 40192601
DOI: 10.1093/jxb/eraf016
PMCID: PMC12192439

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