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Article

A single-locus quantitative genetic model incorporating DNA methylation.

Journal of theoretical biology - 21 Jun 2025

Ayres L, Bovenhuis H, Calus M P L

Abstract excerpt

We describe a single-locus quantitative genetic model that incorporates effects due to DNA methylation. Extending Fisher's decomposition of the genotypic value, we distinguish two quantities to predict an individual's phenotypic or genetic values: the "basic genetic value" and the "expressed genetic value". We show how these quantities relate to the concept of breeding value and derive their corresponding...

Read the complete abstract on PubMed

Topics

DNA Methylation
Models, Genetic
Phenotype
Gene Frequency
Animals
Quantitative Trait Loci
Genotype

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Source

Identifiers

PMID: 40189137
DOI: 10.1016/j.jtbi.2025.112110

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