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Evaluation of phenotypic and genotypic methods for detecting KPC variants

4 Apr 2025

Abstract excerpt

ABSTRACT Klebsiella pneumoniae carbapenemases (KPCs) have spread and diversified extensively. To date, 242 clinical variants have been identified and harbor different hydrolytic capacities, thereby interfering with rapid diagnostic tests. The accurate detection of KPC variants is crucial to guide treatment and control measures in healthcare settings. We constructed KPC variants to assess the mutational impact on...

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PMID: 40178306
DOI: 10.1128/aac.00082-25

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