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Article

A Mendelian randomization study reveals a causal association between NASH and the risk of atrial fibrillation.

Frontiers in endocrinology - 1 Jan 2025

Cheng Biwei, Su Xuekang, He Jue, Gu Yanghui, Chen Mingtai, Wei Yi, Yi Yumeng, Chen Peiying, Lin Xiaojuan, Li Tao, Xu Chong, Liu Qiang, Li Biao

Abstract excerpt

Background: Epidemiological evidence suggests that non-alcoholic fatty liver disease (NAFLD) may increase the risk of atrial fibrillation (AF). However, the findings are inconsistent, and the causality remains to be established. Methods: We conducted two-step, two-sample Mendelian randomization (MR) analysis to assess the association between genetically predicted NAFLD (i.e. chronically elevated serum alanine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40171195
DOI: 10.3389/fendo.2025.1390259
PMCID: PMC11958169

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