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Article

EPAS1 amplifies asthma pathogenesis through JAK2/STAT3-mediated ferroptosis and inflammation

27 Mar 2025

Abstract excerpt

Asthma is a chronic respiratory disorder marked by airway hyperresponsiveness and inflammation, yet the specific molecular mechanisms driving these processes remain only partially understood. This study aims to better understand how the JAK2/STAT3/EPAS1 axis regulates inflammation and ferroptosis in asthma. Asthma-related datasets were retrieved from the Gene Expression Omnibus (GEO) database, and differentially...

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PMID: 40165005
DOI: 10.17305/bb.2025.11334

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