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Identifying key genes and functionally enriched pathways in Th2-high asthma by weighted gene co-expression network analysis

12 May 2022

Abstract excerpt

BACKGROUND: Asthma is a chronic lung disease characterized by reversible inflammation of the airways. The imbalance of Th1/Th2 cells plays a significant role in the mechanisms of asthma. The aim of this study was to identify asthma-related key genes and functionally enriched pathways in a Th2-high group by using weighted gene coexpression network analysis (WGCNA). METHODS: The gene expression profiles of GSE4302,...

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PMID: 35550122
DOI: 10.1186/s12920-022-01241-9

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