Article
Investigation of malondialdehyde as a trait marker associated with familial risk in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives - A longitudinal cohort study.
Free radical biology & medicine - 1 Jun 2025
Coello Klara, Stanislaus Sharleny, Forman Julie Lyng, Kjærstad Hanne Lie, Ormstrup Sletved Kimie Stefanie, Miskowiak Kamilla Woznica, Faurholt-Jepsen Maria, Munkholm Klaus, Poulsen Henrik Enghusen, Vinberg Maj, Lykkesfeldt Jens, Kessing Lars V
Abstract excerpt
AIMS: Increased oxidative stress-generated tissue damage seems to play a pivotal role in the pathophysiology and progression of bipolar disorder (BD). Malondialdehyde (MDA), a product of lipid oxidation, may represent a trait marker in BD associated with familial risk. However, MDA is scarcely studied in patients with newly diagnosed bipolar disorder (BD) and their unaffected relatives (UR). METHODS: In this...
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