Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota

Abstract excerpt

BACKGROUND: Lynch syndrome (LS)-associated colorectal cancer (CRC) always ascribes to pathogenic germline mutations in mismatch repair (MMR) genes. However, the penetrance of CRC varies among those with the same MMR gene mutation. Thus, we hypothesized that the gut microbiota is also involved in CRC development in LS families. METHODS: This prospective, observational study was performed from December 2020 to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Colorectal Cancer Screening and Detection
• Share to Genetic factors in colorectal cancer
• Share to Gut microbiota and health