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Exosome-transmitted HSPA9 facilitates bortezomib resistance by targeting TRIP13/USP1 signaling in multiple myeloma

26 Mar 2025

Abstract excerpt

Resistance to the proteasome inhibitor bortezomib (BTZ) poses a formidable therapeutic challenge in multiple myeloma (MM). Our study aims to analyze the mechanism by which exosomes heat shock 70 kDa protein 9 (HSPA9) secreted by BTZ-resistant MM cells disseminate resistance to BTZ-sensitive MM cells. The serum exosomes were identified by nanoparticle tracking analysis and transmission electron microscopy. Liquid...

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PMID: 40140922
DOI: 10.1186/s12964-025-02158-3

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