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Metronidazole response profiles of Gardnerella species are congruent with phylogenetic and comparative genomic analyses

25 Mar 2025

Abstract excerpt

BACKGROUND: Bacterial vaginosis (BV) affects 20-50% of reproductive-age female patients annually, arising when opportunistic pathogens outcompete healthy vaginal flora. Many patients fail to resolve symptoms with a course of metronidazole, the current first-line treatment for BV. Our study was designed to identify genomic variation associated with metronidazole resistance among strains of Gardnerella vaginalis...

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PMID: 40133961
DOI: 10.1186/s13073-025-01446-4

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