Article
Identification of intrinsically metronidazole-resistant clades of Gardnerella vaginalis.
Diagnostic microbiology and infectious disease - 1 Jan 2016
Schuyler Jessica A, Mordechai Eli, Adelson Martin E, Sobel Jack D, Gygax Scott E, Hilbert David W
Abstract excerpt
Gardnerella vaginalis is associated with bacterial vaginosis (BV), the most common cause of vaginal discharge. Metronidazole is a front-line therapy for BV, and treatment failure and recurrent disease are common problems. Whole-genome sequencing studies have revealed that G. vaginalis has a population structure that consists of 4 clades: clades 1 and 3 are associated with BV, whereas clades 2 and 4 are not. To...
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