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GLI2 inhibits cisplatin sensitivity in gastric cancer through DEC1/ZEB1 mediated EMT

25 Mar 2025

Abstract excerpt

Cisplatin (CDDP) based chemotherapy has emerged as the predominant therapeutic regimen for patients with advanced gastric cancer (GC). However, its efficacy is dampened by the development of chemoresistance, which results in poor prognosis of patients. GLI2, a key transcription factor in the Hedgehog (Hh) signaling pathway, is regarded as a target for cancer therapy. However, the significance of GLI2 for CDDP...

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PMID: 40133270
DOI: 10.1038/s41419-025-07564-6

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