Article
Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics.
Translational psychiatry - 10 Jan 2018
Liu Duan, Ray Balmiki, Neavin Drew R, Zhang Jiabin, Athreya Arjun P, Biernacka Joanna M, Bobo William V, Hall-Flavin Daniel K, Skime Michelle K, Zhu Hongjie, Jenkins Gregory D, Batzler Anthony, Kalari Krishna R, Boakye-Agyeman Felix, Matson Wayne R, Bhasin Swati S, Mushiroda Taisei, Nakamura Yusuke, Kubo Michiaki, Iyer Ravishankar K, Wang Liewei, Frye Mark A, Kaddurah-Daouk Rima, Weinshilboum Richard M
Abstract excerpt
Major depressive disorder (MDD) is a heterogeneous disease. Efforts to identify biomarkers for sub-classifying MDD and antidepressant therapy by genome-wide association studies (GWAS) alone have generally yielded disappointing results. We applied a metabolomics-informed genomic research strategy to study the contribution of genetic variation to MDD pathophysiology by assaying 31 metabolites, including compounds...
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