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Article

Analysis of canine gene constraint identifies new variants for orofacial clefts and stature.

Genome research - 2 May 2025

Buckley Reuben M, Bilgen Nüket, Harris Alexander C, Savolainen Peter, Tepeli Cafer, Erdoğan Metin, Serres Armero Aitor, Dreger Dayna L, van Steenbeek Frank G, Hytönen Marjo K, Parker Heidi G, Hale Jessica, Lohi Hannes, Çınar Kul Bengi, Boyko Adam R, Ostrander Elaine A

Abstract excerpt

Dog breeding promotes within-group homogeneity through conformation to strict breed standards, while simultaneously driving between-group heterogeneity. There are over 350 recognized dog breeds that provide the foundation for investigating the genetic basis of phenotypic diversity. Typically, breed standard phenotypes such as stature, pelage, and craniofacial structure are analyzed through genetic association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40127928
DOI: 10.1101/gr.280092.124
PMCID: PMC12047267

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LCORL
PDGFRA

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