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Article

M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis

22 Mar 2025

Abstract excerpt

AIM: Obstetric antiphospholipid syndrome (OAPS) is a pregnancy-related complication characterized by trophoblast pyroptosis and placental injury induced by antiphospholipid antibodies (aPLs). M2-polarized macrophage-derived exosomes (M2-exos) exert anti-inflammatory, immunomodulatory, and growth-promoting effects in various autoimmune diseases and tumors. However, their role in OAPS is not yet clear. Therefore,...

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PMID: 40127859
DOI: 10.1016/j.lfs.2025.123561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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