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SARS-CoV-2 serotyping based on spike antigenicity and its implications for host immune evasion

11 Mar 2025

Abstract excerpt

BACKGROUND: As SARS-CoV-2 continues to spread and evolve, new variants/sub-variants emerge, raising concerns about vaccine-induced immune escape. Here, we conducted a systematic analysis of the serology and immunogenicity of major circulating variants/sub-variants of SARS-CoV-2 since the outbreak. METHODS: We expressed and purified trimeric S proteins from 21 SARS-CoV-2 variants, with SARS-CoV included as an...

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PMID: 40080947
DOI: 10.1016/j.ebiom.2025.105634

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