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Article

Rapid Development of Unclassified Myeloid Lineage Acute Leukaemia With Trisomy 6 and U2AF1 Mutation.

Journal of cellular and molecular medicine - 1 Mar 2025

Markiewicz Miroslaw, Kopacz Agnieszka, Blajer-Olszewska Beata, Mazur Malwina, Warzybok Katarzyna, Szarawarska Marta, Wojtaszewska Marzena, Moskwa Monika, Dudycz Dominika, Schwarz Ewa, Kosior Katarzyna, Lewandowski Krzysztof

Abstract excerpt

We present a case of acute clonal bone marrow 98% infiltration of atypical myeloid cells with borderline hypogranular/agranular promyelocytes/myelocytes and occasional blast cells maturity, which also formed extramedullary tumours in the chest wall, with isolated trisomy of chromosome 6 and pathogenic variant U2AF1 (S34F) that escapes established acute myeloid leukaemia (AML) diagnostic criteria according to the...

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Topics

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Share to Chromosomes, Human, Pair 6
Share to NRAS gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Splicing Factor U2AF

Share to Trisomy

Source

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Identifiers

PMID: 40066790
DOI: 10.1111/jcmm.70461
PMCID: PMC11894460

Genes

U2AF1
NRAS
ZRSR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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