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Article

Unveiling Clinical and Genetic Distinctions in Pure-Apical Versus Distal-Dominant Apical Hypertrophic Cardiomyopathy.

Journal of the American Heart Association - 18 Mar 2025

Sugiura Kenta, Kubo Toru, Inoue Shunsuke, Nomura Seitaro, Yamada Takanobu, Tobita Takashige, Kuramoto Yuki, Miyashita Yohei, Asano Yoshihiro, Ochi Yuri, Miyagawa Kazuya, Baba Yuichi, Noguchi Tatsuya, Hirota Takayoshi, Yamasaki Naohito, Morita Hiroyuki, Komuro Issei, Kitaoka Hiroaki

Abstract excerpt

BACKGROUND: Original apical hypertrophic cardiomyopathy was characterized by left ventricular hypertrophy confined to the apex below the papillary muscle level. In contrast, apical hypertrophic cardiomyopathy in Western countries often includes hypertrophy extending to the midventricular septum. Recognizing these phenotypic differences is essential as they may influence the clinical prognosis. The aim of this...

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Identifiers

PMID: 40055852
DOI: 10.1161/JAHA.124.038208
PMCID: PMC12132613

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