Article
Sex-dependent associations between addiction-related behaviors and the microbiome in outbred rats.
EBioMedicine - 1 May 2020
Peterson Veronica L, Richards Jerry B, Meyer Paul J, Cabrera-Rubio Raul, Tripi Jordan A, King Christopher P, Polesskaya Oksana, Baud Amelie, Chitre Apurva S, Bastiaanssen Thomaz F S, Woods Leah Solberg, Crispie Fiona, Dinan Timothy G, Cotter Paul D, Palmer Abraham A, Cryan John F
Abstract excerpt
BACKGROUND: Multiple factors contribute to the etiology of addiction, including genetics, sex, and a number of addiction-related behavioral traits. One behavioral trait where individuals assign incentive salience to food stimuli ("sign-trackers", ST) are more impulsive compared to those that do not ("goal-trackers", GT), as well as more sensitive to drugs and drug stimuli. Furthermore, this GT/ST phenotype...
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