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Cell-free DNA in ex-vivo lung perfusate is associated with low-quality lungs and lung transplant outcome

4 Mar 2025

Abstract excerpt

BACKGROUND: Cell-free DNA (cfDNA) in ex-vivo lung perfusion (EVLP) perfusate has been shown to potentially reflect lung injury; however, the relationship between cfDNA concentration with clinical EVLP lung outcomes has not been elucidated. METHODS: A discovery cohort of n = 100 clinical EVLP cases and a validation cohort (n = 50) were used in this single-center, retrospective cohort study. cfDNA was extracted and...

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PMID: 40049261
DOI: 10.1016/j.healun.2025.02.1693

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