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Article

Quantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-type Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2025

Trontzas Ioannis P, He Mengni, Wurtz Anna, Robbins Charles J, Robinson Nathaniel, Bates Katherine, Liu Matthew, Aung Thazin N, Scott Liam, Chan Nay, Burela Sneha, Schillo Jacob, Liebler Daniel C, Hill Salisha, Morrison Ryan D, Vathiotis Ioannis, Syrigos Konstantinos N, Goldberg Sarah B, Politi Katerina, Rimm David L

Abstract excerpt

PURPOSE: Antibody-drug conjugates (ADC) are a promising approach for the management of patients with non-small cell lung cancer (NSCLC). However, only a small subset of patients derive benefit from these therapies. EXPERIMENTAL DESIGN: We used quantitative immunofluorescence assays to measure the levels of four ADC target proteins (HER2, TROP2, HER3, and EGFR) in three NSCLC tissue microarray cohorts stratified...

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Identifiers

PMID: 40047548
DOI: 10.1158/1078-0432.CCR-24-3347
PMCID: PMC12213210

Genes

EGFR

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