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The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation

19 Feb 2025

Abstract excerpt

The p53, often referred to as the "guardian of the genome", is a well-established tumor-suppressor protein that plays a critical role in regulating the cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by the MDM2 protein (murine double minute 2, also known as HDM2 in humans). Disrupting the protein-protein interaction between p53 and MDM2 represents a promising...

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PMID: 40006086
DOI: 10.3390/ph18020274

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