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Article

RAB33A promotes metastasis via RhoC accumulation through non-canonical autophagy in cervical cancer

25 Feb 2025

Abstract excerpt

Cervical cancer metastasis is characterized by the systemic spread of tumor cells. However, the underlying mechanism remains incompletely understood. Herein, we demonstrate that RAB33A promoted metastasis by enhancing RhoC accumulation and that higher RAB33A expression predicted poorer prognosis in patients with cervical cancer. Mechanistically, RhoC typically degraded via canonical autophagy due to the binding...

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PMID: 40000633
DOI: 10.1038/s41419-025-07455-w

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