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Microsatellite instability-high status as a pan-cancer biomarker for immunotherapy efficacy

25 Feb 2025

Abstract excerpt

Microsatellite instability-high (MSI-H) cancers are linked to exceptional benefit from immune checkpoint inhibitors (ICIs), but studies on their efficacy across various MSI-H cancer types are limited. Randomized clinical trials (RCTs) comparing ICIs to chemotherapy in advanced MSI-H/dMMR cancers were systematically reviewed. Eligible studies included 13 RCTs with 1633 MSI-H patients across colorectal, gastric,...

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PMID: 39998698
DOI: 10.1007/s00262-025-03980-x

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